General Information

  • ID:  hor003257
  • Uniprot ID:  Q95104
  • Protein name:  Dynorphin A(1-6)
  • Gene name:  PDYN
  • Organism:  Bos taurus (Bovine)
  • Family:  Opioid neuropeptide precursor family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001515 opioid peptide activity; GO:0031628 opioid receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007600 sensory perception
  • GO CC:  GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus

Sequence Information

  • Sequence:  YGGFLR
  • Length:  6(175-180)
  • Propeptide:  MVWQGLVLAACLLALPSVTADCLAQCSLCAVKTQDGPQPINPLVCSLECQAALQPAQEWERCQGLLSFLTPFTVGLNGKEDLKSKTVLEESSSEPAKHIRPYLKELEKNRFLLSTPAEKNALSSSLVEKLRGLSGRLGEDAESELMGDAQLNDGALEAEARDSNEEEPKEQVKRYGGFLRKYPKRSSEVTGKEAGEGEGGEVGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPSAYYEEL
  • Signal peptide:  MVWQGLVLAACLLALPSVTA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).
  • Mechanism:  NA
  • Cross BBB:  YES
  • Target:  OPRM1
  • Target Unid:  P79350
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q95104-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003257_AF2.pdbhor003257_ESM.pdb

Physical Information

Mass: 80118 Formula: C34H49N9O8
Absent amino acids: ACDEHIKMNPQSTVW Common amino acids: G
pI: 9.35 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: 0 Boman Index: -528
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 65
Instability Index: 4685 Extinction Coefficient cystines: 1490
Absorbance 280nm: 298

Literature

  • PubMed ID:  23046728
  • Title:  The Permeation of Dynorphin A 1-6 Across the Blood Brain Barrier and Its Effect on Bovine Brain Microvessel Endothelial Cell Monolayer Permeability